Event Information:

• Thu

  27

  Nov

  2025

  SC Seminar: Michael Kastor

  10:15Hybrid (Room 32-349 and via Zoom)

  Michael Kastor, Numerical Simulation Group, RPTU Kaiserslautern-Landau

  Title: PIDE-model for phenotypic plasticity of glioblastoma
  

  Abstract:

  Glioblastoma is the most common aggressive type of brain cancer making up approximatly
  14% of tumors originating in the brain. Despite aggressive treatment approaches, tumor
  recurrence is most likely due to intra-tumoral phenotypic heterogeneity and plasticity
  (the ability to change phenotype), resulting in an average survival time of around
  15 months after diagnosis.

  One potential way to mathematically describe the phenotypic cell development of
  glioblastoma is the use of a macroscopic approach via partial integro-differential
  equations (PIDEs), whose parameters are fitted based on biological cell data
  (e.g. RNA-seq data).

  In this seminar, first I will briefly outline the central concepts of the biological
  background needed to tackle a mathematical explanation of the phenotypic landscape of
  glioblastoma, together with different strategies that could be useful for processing
  existing datasets and dealing with their high dimensionality and incompleteness.
  The talk will then focus on a potentially practical PIDE-model and the associated
  parameter identification task.
  Finally, the first partial results of the parameter identification on real patient
  data in UMAP representation will be presented for a simplified model.

  How to join online

  You can join online via Zoom, using the following link:
  https://uni-kl-de.zoom-x.de/j/69269239534?pwd=Z9UOzMpkhMjrxVhll3d49sNHFe9Fd1.1