Prof. Dr. Nicolas Gauger, Chair for Scientific Computing (SciComp), TU Kaiserslautern

SciComp Seminar Series

Please contact Prof. Gauger, if you want to register for an online talk in our SciComp Seminar Series or just to register for the seminar.

A list of the already scheduled talks can be found –> here:

Michael Urs Lars Kastor, Numerical Simulation Group, RPTU Kaiserslautern-Landau

Title: PIDE-model for phenotypic plasticity of glioblastoma

Abstract:

Glioblastoma is the most common aggressive type of brain cancer making up approximatly
14% of tumors originating in the brain. Despite aggressive treatment approaches, tumor
recurrence is most likely due to intra-tumoral phenotypic heterogeneity and plasticity
(the ability to change phenotype), resulting in an average survival time of around
15 months after diagnosis.

One potential way to mathematically describe the phenotypic cell development of
glioblastoma is the use of a macroscopic approach via partial integro-differential
equations (PIDEs), whose parameters are fitted based on biological cell data
(e.g. RNA-seq data).

In this seminar, first I will briefly outline the central concepts of the biological
background needed to tackle a mathematical explanation of the phenotypic landscape of
glioblastoma, together with different strategies that could be useful for processing
existing datasets and dealing with their high dimensionality and incompleteness.
The talk will then focus on a potentially practical PIDE-model and the associated
parameter identification task.
Finally, the first partial results of the parameter identification on real patient
data in UMAP representation will be presented for a simplified model.

How to join online

You can join online via Zoom, using the following link:
https://uni-kl-de.zoom-x.de/j/69269239534?pwd=Z9UOzMpkhMjrxVhll3d49sNHFe9Fd1.1

The goal of the workshop is to give an overview of recent research activities at SciComp. In addition, collaborators from Fraunhofer ITWM, DFKI, MTU Aero Engines, KIT and TU Eindhoven / Bosch will give invited presentations for scientific exchange. Finally, we will brainstorm about future collaboration.

Program

13:00-15:00 Scientific Short Presentations – SciComp (5+5 minutes each)
(Dr. E. Özkaya, Dr. M. Sagebaum, T. Kortus, O. Burghardt, R. Pochampalli, J. Blühdorn, G. Suarez, Dr. L. Chen, L. Fischer, J. Rottmayer, M. Ngowa Msinda, Dr. A. Linke)

15:00-15:15 Coffee break

Keynote Talks
15:15-16:15 Prof. J. Kieseler (KIT)
16:15-17:15 Prof. N. Beishuizen (TU Eindhoven / Bosch)

17:15-18:00 Scientific Short Presentations – Guests (10+5 minutes each)
(M. Padmanabha (ITWM), M. Klostermeier (DFKI), C. Battistoni (MTU))

18:00-18:30 Brainstorming/Thoughts on Future Collaboration (Prof. N. Gauger)

18:30 Workshop Dinner